Early myocardial damage (EMD) and valvular dysfunction after femur fracture in pigs

Abstract Musculoskeletal injuries are the most common reason for surgery in severely injured patients. In addition to direct cardiac damage after physical trauma, there is rising evidence that trauma induces secondary structural and functional damage. Previous research associates hip fractures with appearance of coronary heart disease: As 25% elderly patients developed a major adverse event fracture. 20 male pigs underwent femur fracture operative stabilization via nailing (unreamed, reamed, RIA I new II; each group n = 5). Blood samples were collected 6 h concentration troponin heart-type fatty acid binding protein (HFABP) as biomarkers EMD measured. At baseline transesophageal ECHO (TOE) was performed; invasive arterial left ventricular blood pressure measured evaluate function A systemic elevation HFABP indicate an early myocardial pigs. Furthermore, various changes systolic (ejection fraction output) diastolic (left end-diastolic pressure, mitral valve deceleration time E/A ratio) parameters illustrate impairment heart. These findings accompanied by development valvular dysfunction (pulmonary tricuspid valve). To best our knowledge, we described first context long bone Next elevation, alterations occurred pulmonary insufficiency. Regarding EMD, none techniques (unreamed nailing, reaming, II) superior.